Medicine

Evaluation of anti-oxidant, anti-inflammatory and toxicity potential of ethanolic extract of C.diurnum leaves

Authors

  • Aimen Fatima

    The University of Lahore, Sargodha campus
    Author

  • Roha Ramash

    The University of Lahore, Sargodha campus
    Author

  • Sunbal Khalil Chauhdri

    Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan
    Author

DOI:

https://doi.org/10.71107/kx25gt93

Keywords:

Cestrum diurnum, anti-oxidant , Drug candidate , Inflammatory activity, Toxicity

Abstract

Plants contain several different phytochemicals which can act on various metabolic pathways of the human system at a time thus effectively treating several conditions at once. Main objective of this research was to identify and assess the anti-oxidant, anti-inflammatory and toxicity potential of Cestrum diurnum leaves extract. Phytochemical screening of plant extract was performed, followed by DPPH radical scavenging potential assay, FRAP assay and protein denaturation inhibition assay with both the plant extract and the standard drugs. Hemolytic toxicity was also determined to calculate the safe dosage of plant extract for consumption as a possible drug candidate against oxidative and inflammatory stress conditions. This study confirmed the presence of high quantities of total phenols and total flavonoids which in turn showed notable anti-oxidant potential but slightly reduced reduction potential. Higher protein denaturation inhibition rates indicated the efficiency of plant extract as an effective anti-inflammatory agent and nominal hemolytic activity at 100 μg/ml of plant extract. Further studies are required to ascertain the specific phytocompounds responsible for such activities and their potential applications as pharmacologically active compounds.

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Author Biographies

  • Aimen Fatima, The University of Lahore, Sargodha campus

    Ms. Aimen Fatima is currently working as a lecturer at the University of Lahore, Sargodha campus.

  • Roha Ramash, The University of Lahore, Sargodha campus

    Ms. Roha Ramash is currently working as a lecturer at the University of Lahore, Sargodha campus.

  • Sunbal Khalil Chauhdri, Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan

    Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan

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Published

2025-04-17

Issue

Vol. 1 No. 1 (2025): Conclusions in Medicine

Section

Articles

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Copyright (c) 2025 Aimen Fatima, Roha Ramash, Sunbal Khalil Chauhdry (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Evaluation of anti-oxidant, anti-inflammatory and toxicity potential of ethanolic extract of C.diurnum leaves. (2025). Conclusions in Medicine, 1(1), 33-38. https://doi.org/10.71107/kx25gt93